The underlying causes of Cannabinoid Hyperemesis Syndrome remain unclear. However, researchers have proposed several theories. It is believed that chronic heavy cannabis use may lead to dysregulation of the endocannabinoid system, specifically the receptors in the gastrointestinal tract, which could contribute to the development of CHS. Other factors such as genetic predisposition and individual variations in metabolism may also play a role.
The most effective treatment for CHS is the complete cessation of cannabis use. While this may be challenging for individuals who rely on cannabis for medical reasons, it is crucial for managing the symptoms. Additionally, supportive care is essential to address dehydration and correct any electrolyte imbalances. Intravenous fluids, antiemetic medications, and nutritional support may be necessary in severe cases.